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. 2020 Sep 29;11:585393. doi: 10.3389/fphar.2020.585393

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Copyright © 2020 Defraeye, Bahrami, Ding, Malini, Terrier and Rossi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Amount of drug stored in the epidermis [m_ep,stor(t)] and the cumulative amount of drugs taken up by the blood flow m_bl,up(t) as a function of time for the case where the patch is removed after 72 h. (B) The corresponding flux that is taken up by blood (g_bl,up) as a function of time.