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. 2020 Sep 29;11:585393. doi: 10.3389/fphar.2020.585393

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Copyright © 2020 Defraeye, Bahrami, Ding, Malini, Terrier and Rossi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cumulative amount of drug taken up in the blood as a function of time for the forearm (A), shoulder (B), buttock (C) epidermal thickness averaged for all body sites (D). For comparison, the results of the base case are also depicted. The range corresponding to the simulated average thickness values +/- 2 x standard deviation (µ_i -/+ 2σ_i) is depicted in gray to quantify interpatient variability via the 2.5% and 97.5% quantiles. The thickness of the epidermis (d_ep) and half-uptake time (HUT) are indicated as well..