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. 2020 Sep 29;11:585393. doi: 10.3389/fphar.2020.585393

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Copyright © 2020 Defraeye, Bahrami, Ding, Malini, Terrier and Rossi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug flow as a function of time for drugs released by the patch (g_pt,rel), for drugs taken up by the blood flow (g_bl,up) for the base case and commercial fentanyl patches. The results of an infinite reservoir are also shown.