Table 3.
Material transport properties used in the model for different configurations for fentanyl.
| Parameter | Symbol & unit | Material i | Reference | ||
|---|---|---|---|---|---|
| Layer | Patch | Stratum corneum | Viable epidermis | ||
| Abbreviation | pt | sc | vep | ||
| Validation study | |||||
| Thickness | di [m] | 50.8 x 10-6 | * | 50.8 x 10-6 | (Rim et al., 2005) |
| Diffusion coefficient | Di α [m2 s-1] | 1.00 x 10-13 | * | 3.00 x 10-14 | (Rim et al., 2005) |
| Drug capacity | Ki α (-) | 1 | * | 0.14 | (Rim et al., 2005) |
| Partition coefficient | Ki/j α (-) | – | * | 7.14 (=1/0.14) | (Rim et al., 2005) |
| Parametric study (base case) | |||||
| Thickness | di [m] | 50 x 10-6 | 15 x 10-6 | 70 x 10-6 | Representative values from (Sandby-Møller et al., 2003; Dąbrowska et al., 2018) |
| Diffusion coefficient | Di α [m2 s-1] | 1.0 x 10-13 | Anisotropic: Longitudinal (z) 7.2 x 10-15 Transverse (x, y) 1.05 x 10-12 |
2.0 x 10-11 | (Rim et al., 2009) |
| Drug capacity | Ki α (-) | 1 | 0.14 | 0.00084 (=0.14 x 0.006) | (Rim et al., 2005) |
| Partition coefficient | Ki/j α (-) | – | 7.14 (=1/0.14) | 167 (=1/0.006) | (Rim et al., 2005) |
*not explicitly modeled but included in the epidermis.