Fig. 2.

MKK4 shows individual conformational dynamics with different phosphorylation states. (A) Principal component analysis (PCA) score plot of PC1 and PC2. A single PCA was conducted for all systems, ensuring the comparability of the score-plots. (B) The extreme movements of PC1. (C) The extreme movements of PC2. In B and C, protein is illustrated with rainbow colour (as in Fig. 1A) and the purple arrows indicate the extreme movements related to each principal component. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)