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. 2020 Sep 29;10:544288. doi: 10.3389/fonc.2020.544288

FIGURE 1.

FIGURE 1

Pyruvate kinase M2 (PKM2) is overexpressed in malignant prostate tissue and predicts the poor prognosis of prostate cancer. (A) Expression patterns of PKM2 immunoreactivity in human prostate cancer and adjacent normal tissue; representative image of histopathologic sections of human prostate cancer and adjacent normal tissue are shown (×100); amplified images are also shown (×400). pkm2 gene expression in prostate cancer from the ONCOMINE database. (B) Malignant cancer tissues (n = 69) have a higher expression level compared with the normal tissue (n = 20). (C) Grouped by cancer sample site, pkm2 gene expression was significantly higher in metastasis (n = 35) than primary site (n = 59) (ONCOMINE database). (D) mRNA level of pkm2 was related to higher Gleason scores of advanced prostate cancer. (E) Kaplan–Meier curves demonstrate that high PKM2 expression (black, n = 16) in the ONCOMINE database correlates with decreased survival in prostate cancer compared with PKM2 low (red, n = 12) group.