Table 1.
Patient Characteristics by Treatment Group
| Demographic Characteristic | Unmatched Cohort |
Matched Cohort |
||||||
|---|---|---|---|---|---|---|---|---|
| Total (N = 280) | Usual Care (n = 107) | Ivermectin (n = 173) | P Value | Total (N = 196) | Usual Care (n = 98) | Ivermectin (n = 98) | P Value | |
| Age, y | 59.6 ± 17.9 | 58.6 ± 18.5 | 60.2 ± 17.6 | .45 | 59.6 ± 17.5 | 59.04 ± 17.7 | 60.07 ± 17.4 | .68 |
| Female sex | 127 (45.4) | 43 (41.2) | 84 (48.6) | .17 | 78 (39.8) | 39 (39.8) | 39 (39.8) | 1.0 |
| Race or ethnicity | .36 | 1.0 | ||||||
| Black | 153 (54.6) | 55 (51.4) | 98 (56.6) | 108 (55.1) | 54 (55.1) | 54 (55.1) | ||
| White | 76 (27.1) | 35 (32.7) | 41 (23.7) | 55 (28.1) | 27 (27.6) | 28 (28.6) | ||
| Hispanic | 33 (11.7) | 12 (11.2) | 21 (12.1) | 23 (11.7) | 12 (12.5) | 111 (11.2) | ||
| Other or not identifieda | 13 (4.6) | 5 (4.7) | 13 (7.5) | 10 (5.1) | 5 (5.1) | 5 (5.1) | ||
| Current or former smoker | 46/255 (18.0) | 22/99 (22.3) | 24/156 (15.6) | .40 | 31/180 (22.2) | 20/90 (22.2) | 11/90 (12.2) | .11 |
| No. of comorbidities | 1.66 ± 1.34 | 1.60 ± 1.46 | 1.70 ± 1.27 | .57 | 1.56 ± 1.33 | 1.58 ± 1.43 | 1.53 ± 1.22 | .79 |
| Diabetes | 90 ± 32.1 | 31 ± 29.0 | 59 ± 34.1 | .37 | 59 ± 30.1 | 30 ± 30.6 | 29 ± 29.6 | .88 |
| Cardiac | 43 ± 15.4 | 18 ± 16.8 | 25 ± 14.5 | .59 | 27 ± 13.8 | 16 ± 16.3 | 11 ± 11.2 | .30 |
| Pulmonary | 28 ± 10.0 | 14 ± 13.1 | 14 ± 8.9 | .18 | 18 ± 10.1 | 10 ± 10.2 | 8 ± 8.2 | .62 |
| Obesity | 114 ± 40.7 | 42 ± 39.3 | 72 ± 41.6 | .70 | 79 ± 40.3 | 39 ± 39.8 | 40 ± 40.1 | .88 |
| Renal | 24 ± 8.6 | 10 ± 9.4 | 14 ± 8.1 | .72 | 16 ± 8.2 | 9 ± 9.2 | 7 ± 7.1 | .60 |
| Cancer | 17 ± 6.1 | 8 ± 7.5 | 9 ± 5.2 | .44 | 14 ± 7.1 | 7 ± 7.1 | 7 ± 7.1 | 1.00 |
| Hypertension | 50 ± 17.9 | 13 ± 12.2 | 37 ± 21.4 | .05 | 26 ± 13.2 | 12 ± 12.2 | 14 ± 14.3 | .67 |
| Neurologic | 28 ± 10.0 | 8 ± 7.5 | 20 ± 11.6 | .27 | 17 ± 8.7 | 8 ± 8.2 | 9 ± 9.2 | .80 |
| HIV infection | 9 ± 3.2 | 1 ± 1 | 8 ± 4.6 | .09 | 3 ± 1.5 | 1 ± 1.0 | 2 ± 2.0 | .56 |
| Thyroid | 23 ± 8.2 | 7 ± 6.6 | 16 ± 9.3 | .42 | 15 ± 7.7 | 7 ± 7.1 | 8 ± 8.2 | .79 |
| BMI | 30.0 ± 7.8 | 29.8 ± 7.2 | 30.1 ± 8.2 | .81 | 29.4 ± 6.6 | 29.4 ± 6.3 | 29.4 ± 6.9 | .95 |
| Pulmonary severity | .46 | |||||||
| Severe | 75 (26.8) | 26 (24.3) | 49 (28.3) | .12 | 47 (24.0) | 22 (22.4) | 25 (25.5) | .62 |
| Intubated at study entry | 38 (13.6) | 15 (14.0) | 23 (13.3) | .86 | 25 (12.8) | 11 (11.2) | 14 (14.3) | .52 |
| Heart rate | 86.0 (75.0-98.0) | 86.0 (74.0-97.0) | 86.0 (75.5-98.0) | .65 | 85.5 (74.0-98.0) | 86.0 (73.0-97.5) | 85.0 (74-98.0) | .88 |
| MAP (mm Hg) | 93 (82.3-103.0) | 90 (81.0-103.0) | 94 (83-103) | .24 | 92.5 (82.0-103.0) | 91.0 (81.0-103.2) | 93.0 (82.0-103.0) | .74 |
| MAP ≤ 70 mm Hg | 13/260 (5.0) | 6/89 (6.7) | 7/171 (4.1) | .35 | 7 (3.6) | 4 (4.1) | 3 (3.1) | .70 |
| Corticosteroid | 90 (32.1) | 21 (19.6) | 69 (39.8) | .001 | 46 (23.2) | 21 (21.4) | 25 (25.5) | .5 |
| Hydroxychloroquine | 260 (92.9) | 104 (97.2) | 156 (90.2) | .03 | 190 (96.9) | 95 (96.9) | 95 (96.9) | 1.00 |
| Azithromycin | 243 (86.7) | 99 (92.5) | 144 (83.2) | .03 | 177 (90.3) | 90 (91.8) | 87 (88.7) | .47 |
| Peripheral WBC count (× 109/L) | 7.3 (5.6-10.2; n = 277) | 7.0 (5.7-8.9; n = 106) | 7.6 (5.5-11.1; n = 171) | .41 | 6.9 (5.3-9.3) | 7.0 (5.8-9.0) | 6.9 (5.2-9.8) | .69 |
| Lymphocyte count (× 109/L) | 1.15 (0.78-1.56; n = 260) | 1.14 (0.84-1.49; n = 102) | 1.20 (0.77-1.67; n = 158) | .62 | 1.13 (0.77-1.52) | 1.15 (0.87-1.45) | 1.19 (0.75-1.57) | .88 |
Data are presented as No. (%), mean ± SD, or median (interquartile range), unless otherwise indicated. Current and former smoker is given as a proportion of the population with known smoking status documented in their medical records. MAP = mean arterial pressure.
a
Asian, Native American, Pacific Islander, or not identified.