Figure 1.

Curcumin inhibits the proliferation and viability of HCT-116 cells. (A) HCT-116 cells were treated with three different doses of curcumin (10, 20 and 30 µM) and 5-FU (500 µM) for 24, 36 and 48 h. Cell proliferation was determined using Cell Counting Kit-8 assays. (B) Effects of curcumin and 5-FU on the viability of HCT-116 cells according to a colony formation assay. (C) Quantification of the inhibitory rate in the colony formation assay. Results are presented as the mean ± standard error of the mean (n≥3). *P<0.05 and **P<0.01 vs. control group. 5-FU, 5-fluorouracil; CUR(L), 10 µM curcumin; CUR(M), 20 µM curcumin; CUR(H), 30 µM curcumin; NS, not significant.