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. 2020 Sep 9;44(5):1895–1904. doi: 10.3892/or.2020.7760

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — The level of CK1α mRNA is highly expressed and correlated with poor prognosis in patients with AML. (A) Bone marrow specimens from 67 patients with AML (61 newly diagnosed, 6 achieved CR) and 11 healthy donors were collected. The level of CK1α mRNA was determined by RT-qPCR and GAPDH was used as an internal reference. (B) The level of CK1α mRNA was showed in each FAB subtypes of 61 newly diagnosed patients with AML. (C) Kaplan-Meier survival analysis was performed based on the survival data of 163 AML patients and its CSNK1A1 expression information in the TCGA-LAML database using the UALCAN website. The upper quartile of the expression information was used as a boundary value and differences in survival distributions were evaluated by the log-rank test. CK1α, casein kinase 1α; AML, acute myeloid leukemia; TCGA, Cancer Genome Atlas.