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. 2020 Sep 21;18(9):481. doi: 10.3390/md18090481

Figure 2.

Figure 2

Effect of fucoidan extracts on angiogenic mediators in OEC and MSC mono-culture. MSC (a) and OEC (b) were treated with 100 µg/mL fucoidan for seven days. The expression and protein level of angiogenic markers vascular endothelial growth factor (VEGF), stromal-derived factor 1 (SDF-1), angiopoietin-1 (ANG-1) and ANG-2 were quantified with qPCR and enzyme-linked immunosorbent assay (ELISA), respectively. The mean values of experiments with three individual donors ± s.e.m. were plotted. (c) MSC were treated with 1, 10 and 100 µg/mL fucoidan for seven days. Protein levels of VEGF, SDF-1 and ANG-1 were quantified with ELISA. The mean values of experiments with three individual donors were plotted for every extract. Trend lines visualize the influence of concentration on protein level for each extract. All plotted values were normalized to the control. Significances compared to the control were calculated with Welch’s t-test (* p < 0.05, ** p < 0.01, *** p < 0.001).