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. 2020 Sep 22;44(5):2021–2030. doi: 10.3892/or.2020.7776

Figure 1.

Figure 1.

Increased SPAG6 expression is associated with the poor prognosis of patients with lymphoma and SPAG6 is significantly upregulated in BL cells. (A) The association between the levels of SPAG6 and the overall survival of patients with lymphoma was examined using TCGA database. Data from TCGA were downloaded to integrate the expression and survival data. Survival analysis was performed with the survival R package and using Kaplan-Meier analysis (log-rank test). (B) The mRNA levels of SPAG6 in human normal peripheral-blood B-lymphocytes (IM-9) and BL cell lines (CA46, NAMALWA, Daudi and Raji) were determined by quantitative PCR assay. (C and D) The protein levels of SPAG6 in IM-9, CA46, NAMALWA, Daudi and Raji cells were determined by western blot assay. *P<0.05, **P<0.01. The levels of SPAG6 of CA46, NAMALWA, Daudi and Raji cells were compared with IM-9 cells. SPAG6, sperm-associated antigen 6; BL, Burkitt lymphoma; TCGA, The Cancer Genome Atlas.