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. 2020 Aug 29;12(9):556. doi: 10.3390/toxins12090556

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene arrangements within the cag pathogenecity island (cagPAI) and CagA sequence variations of strain KE21. This Figure depicts the genes arrangement withing the cagPAI of H. pylori KE21 in comparison to those in J99 and 26695 reference strains (A). The genes are drawn as filled arrows. Analysis of sequence variations of CagA indicates that strain KE21 has a well conserved K-Xn-X/RXR motif of its plecstrin homology (PH) domain (B). The C-terminal CagA has three EPIYA segments of type ABC and two CagA-multimerization motifs (CM or CRPIA motif) of type FPLKRHDKVEDLSKVG and FPLKRRSAKVEDLSKVG which stretch proximal and distal to the EPIYA-C, respectively (C).