Table 1.

Summary of cholesterol-dependent cytolysins (CDCs) discussed and subset of diseases.

Toxin Name	Abbreviation	Organism	Diseases
Streptolysin O	SLO	Streptococcus pyogenes	Necrotizing fasciitis, septic shock, cardiomyopathy, pharyngitis
Pneumolysin	PLY	S. pneumoniae	Pneumonia, meningitis, otitis media
Perfringolysin O	PFO	Clostridium perfringens	Gas gangrene
Listeriolysin O	LLO	Listeria monocytogenes	Meningitis/Miscarriage
Suilysin	SLY	S. suis	Meningitis/septicemia
Anthrolysin O	ALO	Bacillus anthracis	Anthrax
Tetanolysin O	TLO	C. tetani	Tetanus
Intermedilysin	ILY	S. intermedius	Brain/liver abscess
Vaginolysin	VLY	Gardnerella vaginalis	Bacterial vaginosis
Lectinolysin	LLY	S. mitis and S. pseudopneumoniae	Endocarditis/septicemia