Table 1.

Symptoms and signs of nutritional optic neuropathy.

Symptoms
Progressive, bilateral, and symmetrical visual impairment
Central or centrocecal scotoma
Dyschromatopsia
Loss of contrast sensitivity
Signs
No relative afferent pupillary defect (RAPD)
Normal or hyperaemic optic disc (early stages)—except for thiamine deficiency where it is swollen already at early stages
Temporal, then diffuse optic disc pallor (late stage)
Thinning of RNFL in papillomacular bundle (early stage)
Thinning of RNFL involves of all the quadrants (late stage)
Normal or near normal latency with significantly reduced amplitude of VEP