Table 3.
The histopathologic and histomorphometric changes of the periovarian and abdominal wall fat pads in NFD or HFD supplied mice.
| Items Groups | Periovarian Fat Pads | Abdominal Wall Fat Pads | ||
|---|---|---|---|---|
| Thickness (mm) | Adipocyte Diameters (μm) | Thickness (mm) | Adipocyte Diameters (μm) | |
| Controls | ||||
| Intact | 1.73 ± 0.67 | 32.25 ± 1.94 | 1.31 ± 0.50 | 39.95 ± 3.81 |
| HFD | 6.67 ± 1.24 a | 108.12 ± 14.91 a | 7.28 ± 1.15 a | 112.47 ± 12.26 a |
| Reference | ||||
| Metformin | 3.35 ± 1.09 ac | 65.58 ± 12.01 ac | 3.45 ± 0.83 ac | 71.04 ± 10.58 ac |
| Test materials—WL | ||||
| 200 mg/kg | 2.24 ± 0.48 c | 39.67 ± 6.80 c | 1.90 ± 0.25 bc | 49.24 ± 10.85 c |
| 100 mg/kg | 2.59 ± 0.46 bc | 49.27 ± 10.54 ac | 2.36 ± 0.56 ac | 56.52 ± 13.82 ac |
| 50 mg/kg | 3.23 ± 0.75 ac | 64.37 ± 16.38 ac | 3.36 ± 1.27 ac | 69.19 ± 15.50 ac |
Values are shown as mean ± SD of eight mice. NFD = Normal pellet diet; HFD = 45% Kcal high-fat diet; WL = Wasabi Leaf/Folium, Wasabia japonica (Miq.) Matsum extracts. a p < 0.01 and b p < 0.05—vs. intact control; c p < 0.01—vs. HFD control.