Table 4.

Changes in pancreas zymogen granule content in NFD or HFD supplied mice.

Groups Items	Control		Reference	Test Materials—WL
	Intact	HFD	Metformin	200 mg/kg	100 mg/kg	50 mg/kg
Zymogen granules (%/mm2 of exocrine)	59.72 ± 11.66	13.09 ± 3.29 a	40.62 ± 11.08 ac	53.54 ± 10.91 c	47.11 ± 10.54 bc	41.58 ± 12.69 ac

Values are shown as mean ± SD of eight mice. NFD = Normal pellet diet; HFD = 45% Kcal high-fat diet; WL = Wasabi Leaf/Folium, Wasabia japonica (Miq.) Matsum extracts. ^a p < 0.01 and ^b p < 0.05—vs. intact control; ^c p < 0.01—vs. HFD control.