Table 2.

Baseline demographics and treatment in the substudy cohort.

Baseline Demographics
Subject	1	2	3	4	5	6	7
Age (years)	11	11	12	9	7	11	15
Weight (kg)	60.3	53.3	45.9	25.8	26.6	45.6	55.8
Height (cm)	152.3	147.5	155.8	124.5	119.7	154.8	174.4
PKU classification	Classical	Classical	Moderate	Classical	Classical	Classical	Classical
Blood Phe on diagnosis (µmol/L)	1700	1680	900	1390	1590	2520	2690
Gender	Female	Female	Male	Male	Male	Male	Male
Ethnicity	Pakistani	Pakistani	White European	White British	Mixed race	White British	White British
Diet and Protein-Substitute Profile
Natural protein allowance (g/day)	4.0	4.0	7.0	3.0	6.5	7.5	18.0
Protein equivalent from usual protein substitutes g/day (g/kg/day)	60.0 (1.0)	60.0 (1.1)	60.0 (1.3)	80.0 (3.1)	60.0 (2.3)	80.0 (1.7)	60.0 (1.2)
Number of different protein substitutes/day	2	2	2	1	2	2	1
Number of doses/day	3	3	4	4	4	4	3
Study Product Treatment Schedule and Preparation
Daily dose (g)	24.0	24.0	24.0	32.0	24.0	24.0	24.0
Protein equivalent from study product (g)	15.0	15.0	15.0	20.0	15.0	15.0	15.0
Total daily protein equivalent from all protein substitutes (g) 1	55.0	55.0	55.0	80.0	60.0	75.0	55.0
Protein equivalent from study product (% of daily intake)	27.3	27.3	27.3	25.0	25.0	20.0	27.3
Method of administration	In fruit juice	In fruit juice	Food and drinks	In fruit juice	In fruit juice and food	Fruit smoothie	Smoothie
Timing of administration of study product	Evening	Evening	Evening	Evening	Morning midday and bedtime	Morning or evening	Morning or evening
Comments on study product	Left some bits behind on cup	Last bit was hard to take	No comments	No comments	No comments	Required blender to mix	No comments

¹ Subject 1, Subject 2 and Subject 6 were 5 g of protein short of their pre-study dose due to differences in sizes of protein substitute sachets/pouches when incorporating the study product with existing protein-substitute diet plan. Abbreviations: Phe: phenylalanine; PKU: phenylketonuria.