Table 3.
Phenylalanine and tyrosine blood levels of the substudy patient cohort during the study.
| Subject | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|
| Target Phe levels (µmol/L) | 120–360 | 120–360 | 120–360 | 120–360 | 120–360 | 120–360 | 120–600 |
| Phenylalanine Levels (µmol/L) | |||||||
| Baseline | 500 | 270 | 60 | 500 | 290 | 430 | 520 |
| Day 7 | 460 | 250 | NA 1 | 385 | 350 | 400 | 260 |
| Tyrosine Levels (µmol/L) | |||||||
| Baseline | 110 | 120 | 50 | 30 | 60 | 50 | 70 |
| Day 7 | 150 | 160 | NA 1 | NA 1 | 40 | 60 | 50 |
| Phenylalanine/Tyrosine Ratio | |||||||
| Baseline | 4.5 | 2.3 | 1.2 | 16.7 | 4.8 | 8.6 | 7.4 |
| Day 7 | 3.1 | 1.6 | NC 1 | NC 1 | 8.8 | 6.7 | 5.2 |
1 Sample labelling issue. NA: not available; NC: not calculable.