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. 2020 Aug 20;8(3):281. doi: 10.3390/healthcare8030281

Table 4.

DOACs half-life as a function of creatinine clearance.

Renal Function
(CRCL, mL/min)		 Dabigatran Rivaroxaban Apixaban Edoxaban
>80 12–17 h 5–9 h (young)
11–13 h (elderly)		 9–12 h 10–14 h
>50 to ≤80 17 h 8.7 h 14.6 h 8.6 h
>30 to ≤50 19 h 9 h 17.6 h 9.4 h
>15 to ≤30 28 h 9.5 h 17.3 h 16.9 h
≤15 No data

CRCL: creatinine clearance.