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. 2020 Sep 16;44(5):1875–1884. doi: 10.3892/or.2020.7770

Figure 2.

Figure 2.

SERPINE1 is upregulated in PTX-resistant BC cell lines. (A) Survival curves for MDA-MB-231 PTX-resistant and -sensitive cells treated with various concentrations of PTX. *P<0.05, **P<0.01. (B) Survival curves for MCF-7 PTX-resistant and -sensitive cells treated with various concentrations of PTX. **P<0.01, ***P<0.001. Some points have no error bars because the standard deviation is too small in A and B. (C) SERPINE1 mRNA levels in MDA-MB-231 PTX-resistant vs. -sensitive cells as assessed by RT-qPCR. ***P<0.001. (D) SERPINE1 mRNA levels in MCF-7 PTX-resistant vs. -sensitive cells as assessed by RT-qPCR. ***P<0.001. (E) SERPINE1 protein expression in MDA-MB-231 and MCF-7 PTX-resistant vs. -sensitive cells as measured by western blotting. **P<0.01. SERPINE1, serine protease inhibitor, clade E member 1; PTX, paclitaxel; BC, breast cancer; RT-qPCR, reverse transcription-quantitative polymerase chain reaction. *P<0.05, **P<0.01, ***P<0.001.