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. 2020 Sep 16;44(5):1875–1884. doi: 10.3892/or.2020.7770

Figure 6.

Figure 6.

VEGFA is regulated by SERPINE1 and mediates PTX resistance in BC cells. (A) Survival curves for MDA-MB-231 PTX-resistant cells with/without SERPINE1 suppression and supplemented with VEGFA. *P<0.05, **P<0.01. (B) Survival curves for MCF-7/PTX cells with/without SERPINE1 suppression and supplemented with VEGFA. Some points have no error bars because the standard deviation was too small in A and B. *P<0.05, **P<0.01. (C) Flow cytometric evaluation of apoptosis among BC cells with/without SERPINE1 suppression and treated with VEGFA. **P<0.01 vs. NC group; ##P<0.01 vs. sh-SERPINE1 group. (D) Expression of VEGFA protein in BC cells with/without SERPINE1 suppression and treated with VEGFA. **P<0.01. VEGFA, vascular endothelial growth factor A; SERPINE1, serine protease inhibitor, clade E member 1; PTX, paclitaxel; BC, breast cancer.