Table 1. Characteristics of the Study Cohort by APOE Genotype.
| Characteristic | APOE | P value | |||||
|---|---|---|---|---|---|---|---|
| ε22 (n = 25) | ε23 (n = 449) | ε33 (n = 2409) | ε24 (n = 115) | ε34 (n = 1295) | ε44 (n = 139) | ||
| Age, mean (SD), y | 71.1 (4.1) | 71.9 (4.9) | 71.5 (4.8) | 71.5 (5.0) | 70.7 (4.3) | 69.8 (3.8) | <.001 |
| Women, No. (%) | 16 (64.0) | 245 (54.6) | 1455 (60.4) | 66 (57.4) | 771 (59.5) | 81 (58.3) | .32 |
| Race No. (%) | |||||||
| White | 25 (100) | 395 (88.0) | 2188 (90.8) | 103 (89.6) | 1203 (92.9) | 128 (92.1) | .003 |
| Black | 0 | 31 (6.9) | 71 (2.9) | 9 (7.8) | 41 (3.2) | 7 (5.0) | |
| Asian | 0 | 15 (3.3) | 117 (4.9) | 2 (1.7) | 33 (2.6) | 2 (1.4) | |
| American Indian | 0 | 1 (0.2) | 3 (0.1) | 0 | 4 (0.3) | 1 (0.7) | |
| Native Hawaiian | 0 | 0 | 1 (0.04) | 0 | 1 (0.08) | 0 | |
| Multiple | 0 | 4 (0.9) | 14 (0.6) | 0 | 9 (0.7) | 0 | |
| Unknown | 0 | 3 (0.7) | 15 (0.6) | 1 (0.9) | 4 (0.3) | 1 (0.7) | |
| Ethnicity, No. (%) | |||||||
| Hispanic or Latino | 0 | 8 (1.8) | 89 (3.7) | 6 (5.2) | 29 (2.2) | 6 (4.3) | .21 |
| Non-Hispanic or non-Latino | 25 (100) | 438 (97.6) | 2300 (95.5) | 108 (93.9) | 1255 (96.9) | 133 (95.7) | |
| Unknown | 0 | 3 (0.7) | 20 (0.8) | 1 (0.9) | 11 (0.8) | 0 | |
| Education, mean (SD), y | 17.2 (3.5) | 16.5 (3.1) | 16.5 (2.8) | 16.6 (3.2) | 16.7 (2.8) | 16.5 (2.7) | .70 |
| Cardiovascular Risk Score, mean (SD) | –0.06 (1.01) | –0.09 (0.98) | 0.00 (0.99) | 0.16 (0.86) | –0.03 (1.01) | –0.14 (0.96) | .08 |
| Aβ positive, No. (%) | 4 (16.0) | 82 (18.3) | 562 (23.3) | 47 (40.9) | 702 (54.2) | 115 (82.7) | <.001 |
| Aβ SUVR, estimated mean (95% CI) | 1.02 (0.95-1.09) | 1.02 (1.01-1.04) | 1.05 (1.04-1.06) | 1.11 (1.08-1.14) | 1.18 (1.17-1.19) | 1.31 (1.28-1.34) | <.001 |
Abbreviations: Aβ, β-amyloid; APOE, apolipoprotein E; SUVR, standardized uptake value ratio.