Table 2.
Single-nucleotide polymorphisms (SNPs) most strongly associated with hypertension susceptibility loci in the Korean population, according to sodium intake.
| SNP | Chr:BP | A1 | MAF | Gene | Feature | Cluster SNP * | OR (95% CI) | p | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Present Study | EAS | EUR | AMR | ||||||||
| Participants with sodium intake <2 g/day | |||||||||||
| rs67617923 | 2:54968517 | A | 0.063 | 0.074 | 0.160 | 0.098 | EML6 | intron variant | rs72806698; rs67246257; rs67514855 | 1.294 (1.187–1.410) | 4.29 × 10−9 |
| rs16998073 | 4:81184341 | T | 0.347 | 0.360 | 0.268 | 0.267 | FGF5 | upstream gene variant | rs12509595; rs10857147 | 1.245 (1.190–1.302) | 1.14 × 10−21 |
| rs11191582 | 10:104913653 | A | 0.227 | 0.265 | 0.089 | 0.193 | NT5C2 | intron variant | rs11191479; rs11191484; rs72050190; rs145010450; rs10883815 | 0.849 (0.806–0.895) | 1.08 × 10−9 |
| rs11105378 | 12:90090741 | T | 0.372 | 0.310 | 0.141 | 0.112 | ATP2B1–LINC00936 | intergenic region | rs2681485; rs7136259; rs11105377; rs1401982; rs1689040 | 0.874 (0.836–0.915) | 4.67 × 10−9 |
| Participants with sodium intake ≥2 g/day | |||||||||||
| rs12509595 | 4:81182554 | C | 0.347 | 0.361 | 0.267 | 0.267 | PRDM8–FGF5 | intergenic region | rs16998073; rs10857147 | 1.228 (1.181–1.277) | 7.46 × 10−25 |
| rs6913309 | 6:32339840 | A | 0.212 | 0.139 | 0.310 | 0.244 | C6orf10–HLA-DQB1 | upstream gene variant | N/A | 1.145 (1.094–1.197) | 4.23 × 10−9 |
| rs112735431 | 17:78358945 | A | 0.011 | 0.002 | 0.000 | 0.000 | RNF213 | missense variant | rs138309870 | 1.706 (1.446–2.012) | 2.38 × 10−10 |
| rs3819496 | 8:143923891 | G | 0.312 | 0.321 | 0.421 | BP0.442 | GML–CYP11B1 | intron variant | rs3753123; rs143247792; rs4527848; rs4606038; rs28524031 | 0.892 (0.857.0.929) | 3.73 × 10−8 |
| rs140473396 | 10:104795885 | GAC | 0.247 | 0.285 | 0.097 | 0.197 | CNNM2–NT5C2 | intron variant | rs11191479; rs11191484; rs72050190; rs145010450; rs10883815 | 0.836 (0.800–0.873) | 1.11 × 10−15 |
| rs12229654 | 12:111414461 | G | 0.141 | 0.159 | 0.000 | 0.000 | MYL2–CUX2 | intergenic region | rs149607519; rs148177611; rs2188380; rs12227162 | 0.834 (0.787–0.883) | 5.25 × 10−10 |
| rs1887320 | 20:10965998 | G | 0.478 | 0.540 | 0.461 | 0.264 | JAG1 | intergenic region | rs6108787; rs1327235; rs6108789; rs913220 | 0.892 (0.859–0.925) | 1.45x10−9 |
SNP, single-nucleotide polymorphism; Chr, chromosome; BP, base pair; EAS, East Asian; EUR, European; AMR, American; N/A, not applicable; MAF, major allele frequency; A1, minor allele; OR, odds ratio; 95% CI, 95% confidence interval. * The cluster SNP is the top five SNPs with an R2 value of 0.8 or higher, and within a ±200 kb range.