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. 2020 Oct 12;180(12):1638–1646. doi: 10.1001/jamainternmed.2020.4748

Table. Summary of Outcomes for the Main Analysis Comparing PCI vs CABG and for the Subgroup Analysesa.

Outcomes No. of studies No. of patients Fixed-effect model Random-effects model Heterogeneity
IRR (95% CI) P value P value for interaction IRR (95% CI) P value P value for interaction I2, % P value
All-cause mortality 22 13 490 1.17 (1.05-1.29) .003 NA 1.13 (0.97-1.31) .12 NA 31.2 .08
PCI with drug-eluting stents 9 8857 1.22 (1.09-1.38) <.001 .19 1.22 (1.06-1.41) .006 .51 15.8 .30
PCI with bare-metal stents 11 4018 1.04 (0.84-1.29) .70 .19 1.08 (0.78-1.50) .63 .51 40.6 .08
Left main disease 5 3995 1.11 (0.91-1.35) .32 .56 0.99 (0.73-1.36) .97 .37 41.5 .15
Other vessel disease 17 9495 1.19 (1.06-1.33) .004 .56 1.17 (0.98-1.40) .09 .37 31.4 .11
Cardiac mortality 17 12 471 1.24 (1.05-1.45) .009 NA 1.16 (0.91-1.48) .24 NA 43.8 .03
PCI with drug-eluting stents 8 8597 1.31 (1.09-1.58) .004 .21 1.24 (0.89-1.73) .21 .46 62.1 .01
PCI with bare-metal stents 9 3874 1.04 (0.76-1.43) .79 .21 1.04 (0.74-1.45) .84 .46 5.9 .39
Left main disease 3 3689 0.96 (0.70-1.30) .78 .06 0.93 (0.64-1.35) .71 .20 27.4 .25
Other vessel disease 14 8782 1.36 (1.13-1.64) .001 .06 1.27 (0.95-1.70) .11 .20 41.1 .06
Noncardiac mortality 16 12 341 1.19 (1.00-1.41) .046 NA 1.19 (1.00-1.42) .05 NA 3.0 .42
PCI with drug-eluting stents 7 8467 1.28 (1.04-1.57) .02 .22 1.30 (1.00-1.69) .05 .23 27.1 .22
PCI with bare-metal stents 9 3874 1.02 (0.75-1.38) .91 .22 1.02 (0.75-1.38) .91 .23 0.0 .68
Left main disease 3 3689 1.41 (1.05-1.89) .02 .15 1.41 (1.05-1.89) .02 .17 0.0 .64
Other vessel disease 13 8652 1.09 (0.88-1.34) .43 .15 1.10 (0.88-1.36) .42 .17 4.2 .40

Abbreviations: CABG, coronary artery bypass grafting; IRR, incidence rate ratio; NA, not applicable; PCI, percutaneous coronary intervention.

a

In all subgroup analyses, the reference is CABG. Differences were calculated using P for interaction.