Table. Summary of Outcomes for the Main Analysis Comparing PCI vs CABG and for the Subgroup Analysesa.
Outcomes | No. of studies | No. of patients | Fixed-effect model | Random-effects model | Heterogeneity | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IRR (95% CI) | P value | P value for interaction | IRR (95% CI) | P value | P value for interaction | I2, % | P value | ||||||
All-cause mortality | 22 | 13 490 | 1.17 (1.05-1.29) | .003 | NA | 1.13 (0.97-1.31) | .12 | NA | 31.2 | .08 | |||
PCI with drug-eluting stents | 9 | 8857 | 1.22 (1.09-1.38) | <.001 | .19 | 1.22 (1.06-1.41) | .006 | .51 | 15.8 | .30 | |||
PCI with bare-metal stents | 11 | 4018 | 1.04 (0.84-1.29) | .70 | .19 | 1.08 (0.78-1.50) | .63 | .51 | 40.6 | .08 | |||
Left main disease | 5 | 3995 | 1.11 (0.91-1.35) | .32 | .56 | 0.99 (0.73-1.36) | .97 | .37 | 41.5 | .15 | |||
Other vessel disease | 17 | 9495 | 1.19 (1.06-1.33) | .004 | .56 | 1.17 (0.98-1.40) | .09 | .37 | 31.4 | .11 | |||
Cardiac mortality | 17 | 12 471 | 1.24 (1.05-1.45) | .009 | NA | 1.16 (0.91-1.48) | .24 | NA | 43.8 | .03 | |||
PCI with drug-eluting stents | 8 | 8597 | 1.31 (1.09-1.58) | .004 | .21 | 1.24 (0.89-1.73) | .21 | .46 | 62.1 | .01 | |||
PCI with bare-metal stents | 9 | 3874 | 1.04 (0.76-1.43) | .79 | .21 | 1.04 (0.74-1.45) | .84 | .46 | 5.9 | .39 | |||
Left main disease | 3 | 3689 | 0.96 (0.70-1.30) | .78 | .06 | 0.93 (0.64-1.35) | .71 | .20 | 27.4 | .25 | |||
Other vessel disease | 14 | 8782 | 1.36 (1.13-1.64) | .001 | .06 | 1.27 (0.95-1.70) | .11 | .20 | 41.1 | .06 | |||
Noncardiac mortality | 16 | 12 341 | 1.19 (1.00-1.41) | .046 | NA | 1.19 (1.00-1.42) | .05 | NA | 3.0 | .42 | |||
PCI with drug-eluting stents | 7 | 8467 | 1.28 (1.04-1.57) | .02 | .22 | 1.30 (1.00-1.69) | .05 | .23 | 27.1 | .22 | |||
PCI with bare-metal stents | 9 | 3874 | 1.02 (0.75-1.38) | .91 | .22 | 1.02 (0.75-1.38) | .91 | .23 | 0.0 | .68 | |||
Left main disease | 3 | 3689 | 1.41 (1.05-1.89) | .02 | .15 | 1.41 (1.05-1.89) | .02 | .17 | 0.0 | .64 | |||
Other vessel disease | 13 | 8652 | 1.09 (0.88-1.34) | .43 | .15 | 1.10 (0.88-1.36) | .42 | .17 | 4.2 | .40 |
Abbreviations: CABG, coronary artery bypass grafting; IRR, incidence rate ratio; NA, not applicable; PCI, percutaneous coronary intervention.
In all subgroup analyses, the reference is CABG. Differences were calculated using P for interaction.