Skip to main content
. 2020 Sep 4;44(5):1971–1984. doi: 10.3892/or.2020.7751

Figure 1.

Figure 1.

miR-216a-5p is expressed at a lower level in ESCC specimens, and its low expression predicts a worse prognosis of ESCC. (A) The potential binding site of miR-216a-5p in the KIAA0101 3′UTR. (B) The relative expression levels of miR-216a-5p in ESCC specimens and adjacent normal tissues were quantified by qPCR; n=29 for the control group; n=29 for the ESCC group. (C and D) The Kaplan-Meier cumulative survival curves of 83 patients with ESCC who were grouped by their median expression levels of miR-216a-5p. The ESCC patients with lower miR-216a-5p expression displayed shorter disease-free survival (DFS; C) and overall survival (OS; D) (both P<0.0001 for DFS, P=0.0073 for OS); n=41 for the miR-216-5p low group; n=42 for the miR-216-5p high group. (E) Representative IHC images showing the different staining patterns of KIAA0101 expression with negative/weak/moderate/strong intensities. Scale bar, 50 µm. (F) miR-216a-5p expression in the ESCC specimens with moderate/strong KIAA0101 staining (n=16) and negative/weak KIAA0101 staining (n=13) was quantified by qPCR. ***P<0.001. ESCC, esophageal squamous cell carcinoma; IHC, immunohistochemistry.