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. 2020 Sep 29;10:573822. doi: 10.3389/fonc.2020.573822

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Copyright © 2020 Liu, Liu, Lyu, Lu, Cui, Wang, Li, Mou, Deng and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis between the aGVHD and the cytokine levels or CAR-T cell levels. (A–D) The peaks of the cytokines in the anti-CD19-CAR T-cell therapy were uncorrelated with aGVHD levels. (E,H) The peaks of IL-6 and TNF-a in grade I-II in the aGVHD group were lower than those of the grade III-IV in the aGVHD group during the occurrence of aGVHD. (F,G) The peaks of the IL-2R and IL-8 during the occurrence of aGVHD were uncorrelated with aGVHD levels. (I–L) The peaks of anti-CD19-CAR T cells and anti-CD19-CAR gene were uncorrelated with aGVHD levels during the anti-CD19-CAR T-cell therapy and the occurrence of aGVHD. (N) The CD3+CD8+CD4- percentages in grade I-II in the aGVHD group were lower than that of the grade III-IV in the aGVHD group. (M,O,P) The CD3+ percentage, the CD3+ absolute value and the CD3+CD8+CD4- absolute value were uncorrelated with aGVHD levels during the occurrence of aGVHD.