Table A10.
Quality assessment of included animal studies.
| Author (Year) | Any Randomization | Any Blinding | Sample Size Calculation | Conflict of Interest statement | Free of Experimental Unit of Analysis Errors | Random Group Allocation (Selection) | Groups Similar at Baseline (Selection) | Blinded Group Allocation (Selection) | Random Housing (Performance) | Blinded Interventions (Performance) | Random Outcome Ass. (Detection) | Blinded Outcome Ass. (Detection) | Reporting of Drop-Outs (Attrition) | Selective Outcome Reporting (Reporting) | Other Biases |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abdel-Wanhab (1999) [115] | Y | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Alexander (2004) [34] | N | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | H | ? | ? |
| Altun (2008) [35] | N | N | N | N | Y | ? | ? | ? | H | H | ? | ? | ? | ? | ? |
| Bai (2012) [109] | Y | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Balansky (2009) [106] | N | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Bass (2017) [58] | Y | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Batistel (2017) [128] | Y | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Beaudoin (1981) [40] | N | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Bérard (2010) [59] | Y | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Birch (2016) [127] | Y | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Bourdon (2016) [44] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | H | ? | L |
| Brunner (1978) [43] | N | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Bursztyn (2003) [45] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Cai (2018) [66] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | H | ? | L |
| Caporossi (2014) [42] | N | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Chandrashekar (1977) [116] | N | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Che (2013) [70] | Y | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Chin (1991) [46] | Y | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Clements (2017) [129] | Y | N | N | N | Y | ? | ? | ? | L | ? | ? | ? | L | ? | ? |
| Crane (2016) [52] | Y | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Cruz (2014) [99] | N | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Cruz (2016) [100] | N | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Da Costa (2014) [47] | Y | N | N | N | Y | ? | ? | ? | H | ? | ? | ? | L | ? | ? |
| Dallanora (2017) [69] | Y | N | N | Y | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Fuji (1971) [117] | N | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Gao (2012) [71] | Y | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Garbossa (2015) [72] | N | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | H | ? | ? |
| Gauthier (2009) [123] | Y | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Gonzalez-Anover (2017) [68] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | ? | ? | ? |
| Greene (2011) [33] | Y | N | N | Y | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Guo (2016) [73] | Y | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Hashimoto (2012) [120] | N | N | N | Y | Y | ? | ? | ? | ? | ? | ? | ? | H | ? | L |
| Helmbrecht (1996) [48] | Y | Y | N | N | N | ? | ? | ? | ? | L | ? | L | ? | ? | ? |
| Herrera (2017) [121] | Y | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Jacometo (2016) [130] | Y | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | H | ? | ? |
| Janovick Guretzky (2006) [151] | Y | N | N | N | Y | ? | H | ? | ? | ? | ? | ? | ? | ? | ? |
| Koeners (2007) [38] | N | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Koz (2010) [118] | Y | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Li (2010) [74] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Li (2014) [75] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Li (2015) [76] | Y | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Lin (2011) [113] | N | N | N | Y | Y | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Liu (2012) [77] | Y | N | N | N | N | ? | L | ? | ? | ? | ? | ? | ? | ? | ? |
| Liu (2016) [125] | Y | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Madsen (2017) [60] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Mateo (2007) [61] | Y | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Mateo (2008) [62] | Y | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Matsueda (1982) [97] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | H | ? | ? |
| Mawatari (2004) [102] | N | N | N | N | Y | L | L | ? | ? | ? | ? | ? | H | ? | ? |
| Miller (2014) [108] | Y | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | H | ? | ? |
| Moazzen (2014) [107] | N | N | N | Y | N | ? | L | ? | ? | ? | ? | ? | ? | ? | L |
| Mori (1999) [98] | N | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Navarro (2005) [148] | N | N | N | N | N | ? | N | ? | ? | ? | ? | ? | ? | ? | ? |
| Othmani Mecif (2017) [124] | N | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Peine (2018) [53] | Y | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Podjarny (2001a) [49] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | ? | ? | ? |
| Podjarny (2001b) [91] | N | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Podjarny (1993) [90] | N | N | N | N | N | ? | N | ? | ? | ? | ? | ? | ? | ? | ? |
| Podjarny (1997) [92] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | ? | ? | ? |
| Quesnel (2014) [64] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | H | ? | ? |
| Schooley (2002) [50] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | H | ? | ? |
| Sharkey (2001) [51] | Y | N | N | N | N | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Soto-Blanco (2001) [114] | N | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Sun (2018) [55] | Y | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Sun (2017) [54] | Y | N | N | Y | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Thomas (2009) [110] | Y | N | N | Y | Y | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Thompson (2011) [122] | N | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Tran (2017) [39] | Y | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | L |
| Tsiplakou (2017) [126] | N | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |
| Ventrucci (2001) [101] | N | N | N | N | N | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Ventrucci (2002) [150] | N | N | N | Y | N | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Viana (2013) [103] | Y | N | N | N | Y | ? | ? | ? | ? | ? | L | ? | L | ? | ? |
| Viau (1973) [119] | N | N | N | N | Y | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Vosatka (1998) [36] | Y | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | H | ? | ? |
| Wang (2018) [105] | Y | N | N | Y | Y | ? | ? | ? | ? | ? | ? | ? | H | ? | L |
| Wu (2012) [63] | Y | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Xu (2017) [104] | N | N | N | N | Y | ? | L | ? | ? | ? | ? | ? | L | ? | ? |
| Xu (2018) [131] | N | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | H | ? | ? |
| Yang (2000) [111] | Y | Y | N | N | N | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Zeng (2008) [37] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Zeng (2012) [41] | Y | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Zenobi (2018a) [132] | Y | Y | N | N | Y | ? | ? | ? | ? | ? | ? | ? | H | ? | ? |
| Zenobi (2018b) [152] | Y | N | N | N | N | ? | ? | ? | ? | ? | ? | ? | L | ? | ? |
| Zhang (2014) [65] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Zhang (2016a) [56] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Zhang (2016b) [57] | Y | N | N | Y | N | ? | L | ? | ? | ? | ? | ? | L | ? | L |
| Zhang (2018) [112] | Y | N | N | Y | N | ? | ? | ? | ? | ? | ? | ? | L | ? | L |
| Zhu (2018) [67] | Y | N | N | Y | Y | ? | L | ? | ? | ? | L | ? | L | ? | L |
| Zhu (2015) [149] | Y | N | N | Y | Y | ? | L | ? | ? | ? | ? | ? | L | ? | L |
Quality assessment using the SYRCLE risk of bias tool: The first five columns represent the reporting of key study quality indicators; the last ten columns entail the risk of bias assessment. Y = yes, reported; N = no, not reported; H = High risk of bias; L = Low risk of bias; ? = unclear risk of bias.