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. 2020 Aug 19;44(5):2067–2079. doi: 10.3892/or.2020.7743

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — eIF3a knockdown inhibits proliferation, migration and invasion in HCC cells. (A) Western blotting was performed to confirm the transfection efficiency. (B) CCK8 assay revealed that knockdown of eIF3a markedly retarded the proliferation of HCCLM3 cells. (C) HCCLM3 cells transfected with si-eIF3a exhibited restrained proliferation by Edu assay. (D) Transwell assay showed that eIF3a knockdown impaired migration and invasion in HCCLM3 cells. (E) The E-cadherin expression was increased while the expression of vimentin and N-cadherin was reduced by eIF3a knockdown. Scale bars, 20 µm. *P<0.05.