Figure 3.

Transcriptional regulation of cytolysin/hemolysin and the secreted phospholipase genes in (a) V. cholerae, (b) V. vulnificus, and (c) V. anguillarum. Note that the phospholipase gene is divergently transcribed from the cytolysin/hemolysin gene in V. cholerae and V. anguillarum, but not in V. vulnificus. Transcription start sites and −10/−35 boxes are indicated by bent arrows and thick short lines, respectively. Solid arrows and dotted blunt lines represent the binding of positive and negative regulators, respectively. Binding sites for the positive and negative regulators are indicated by red and blue framed boxes, respectively. Black circles in Fur are irons, whereas black stars in CRP are cAMPs. HLYUB, HlyU binding site; FURB, Fur binding site; HAPRB1, HapR binding site 1; and so on.