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. 2020 Aug 29;12(9):555. doi: 10.3390/toxins12090555

Table 3.

Acute exposure risk assessment of the DON metabolites, OTA, and ZEN, with full mycotoxin extraction into the beverages (worst-case scenario).

Tea variety Mycotoxin Concentration (µg kg−1) PDI (µg kg−1 bw day−1) PDI/TDI (%) ***
UB Max UB Max UB Max
Green OTA 0.60 3.40 2.96 × 10−5 1.68 × 10−4 0.17 0.98
AFB1 0.47 2.99 2.32 × 10−5 1.47 × 10−4 0.01 0.09
∑(AFs) * 1.55 7.67 7.64 × 10−5 3.78 × 10−4 0.04 0.22
DON 127 859 6.26 × 10−3 4.23 × 10−2 0.63 4.23
∑(DON derivatives) ** 740 4512 3.65 × 10−2 2.22 × 10−1 3.60 22.2
Black OTA 0.97 7.70 4.41 × 10−5 3.50 × 10−4 0.26 2.05
AFB1 2.36 39 1.07 × 10−4 1.77 × 10−3 0.06 1.04
∑(AFs) * 6.35 103 2.88 × 10−4 4.68 × 10−3 0.17 2.75
DON 28.5 211 1.29 × 10−3 9.59 × 10−3 0.13 0.96
∑(DON derivatives) ** 103 549 4.68 × 10−3 2.49 × 10−2 1.00 2.50
Pu-erh OTA 0.71 4.05 1.84 × 10−5 1.86 × 10−4 0.19 1.08
AFB1 1.30 9.17 5.91 × 10−5 4.17 × 10−4 0.03 0.25
∑(AFs) * 3.18 20.1 1.44 × 10−4 9.13 × 10−4 0.08 0.54
DON 2221 8946 4.06 × 10−1 4.06 × 10−1 10.1 40.6
∑(DON derivatives) ** 5461 17360 7.89 × 10−1 7.89 × 10−1 24.8 78.9
ZEN 11.3 56.1 5.13 × 10−4 2.76 × 10−3 0.20 1.11
Peppermint OTA 2.99 4.2 1.07 × 10−4 1.51 × 10−4 0.63 0.88
AFB1 2.84 5.62 1.02 × 10−4 2.02 × 10−4 0.06 0.12
∑(AFs) * 8.16 15.7 2.93 × 10−4 5.63 × 10−4 0.17 0.33
DON 567 953 7.67 × 10−2 3.42 × 10−2 2.03 3.42
∑(DON derivatives) ** 3599 5631 1.29 × 10−1 2.02 × 10−1 12.9 27.7

UB: upper-bound level of mean. * ∑(AFs): the total concentration of AFB1, AFB2, AFG1, and AFG2. ** ∑(DON derivatives): the total concentration of DON, D3G, 3-AcDON, and 15-AcDON; TDI (DON) = 1 µg kg−1 bw day−1, TDI(∑(DON metabolites)) = 1; TDI(OTA) = 0.0171 µg kg−1 bw day−1; TDI(ZEN) = 0.25 µg kg−1 bw day−1. *** For sum of aflatoxins, the benchmark dose lower confidence limit (BMDL10) for a 10% increase in cancer incidence obtained from animal study data modelling (170 ng kg−1 bw day−1) was considered.