Figure 1.

Selective increase in E06 IgM antibody in the plasma of Cd1d^−/−Ldlr^−/− mice. Relative plasma IgM titers specific for (A) E06 IgM (1:100 dilution), and (B) MDA-LDL (1:200 dilution), Cu-OxLDL (1:200 dilution) and total IgM (1:750 dilution) in female and male Ldlr^−/−, Jα18^−/−Ldlr^−/− and Cd1d^−/−Ldlr^−/− mice fed western type diet for 4 weeks were determined by ELISA. The level of each antibody is expressed relative to the level in Ldlr^−/− mice. The results are expressed as the mean ± SEM with 4 to 8 animals per group. Significance: * p < 0.0001 vs. Ldlr^−/− mice.