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. 2020 Jul 3;9(3):30. doi: 10.3390/antib9030030

Figure 2.

Figure 2

E06 IgM-secreting cells (ISC) are increased in the spleen of Cd1d−/−Ldlr−/− mice. Quantitation of the ELISPOT analysis of cells in the (A) spleen and (B) peritoneal cavity of chow fed Ldlr−/−, Jα18−/−Ldlr−/− and Cd1d−/−Ldlr−/− mice producing E06 IgM, total IgM and MDA-LDL IgM. The number of E06 and MDA-LDL IgM-secreting cells are expressed per 100 ISC. The results are the mean ± SEM of n = 11–14 Ldlr−/− and Cd1d−/−Ldlr−/− mice pooled from triplicate independent experiments and n = 3–7 Jα18−/−Ldlr−/− mice pooled from two independent experiments for splenocytes and n = 5–14 Ldlr−/− and Cd1d−/−Ldlr−/− mice pooled from two independent experiments and n = 3–5 Jα18−/−Ldlr−/− mice pooled from two independent experiments for peritoneal cells. Significance: * p < 0.0001 and ** p < 0.01 vs. Ldlr−/− mice.