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. 2020 Aug 20;12(9):533. doi: 10.3390/toxins12090533

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Extracted ion chromatograms from LC-MS/MS SRM analysis for dihydro-DTX1 ((M-H)⁻ m/z 819.5), fragmenting to m/z 255.2 (for quantitation) (black trace) and 151.1 (for confirmation) (red trace), for (A) 26–27 min fraction from bioactivity guided fractionation procedure on mussel (M. edulis) extract from 2016 D. norvegica bloom in the Gulf of Maine, (B) filtered water sample collected during 2018 D. norvegica bloom in the Gulf of Maine, and (C) representative mussel (M. edulis) sample collected during 2018 D. norvegica bloom in the Gulf of Maine. OA ((M-H)⁻ m/z 803.5), DTX1 ((M-H)⁻ m/z 817.5), and DTX2 ((M-H)⁻ m/z 803.5), all fragmenting to m/z 255.2 and 151.1, were monitored for and were not detected (not shown). Panel (D) shows extracted ion chromatograms for a 12.8 ng/mL standard mix of OA, DTX1, and DTX2 run in the same analytical batch as panel C for comparison of relative retention times using the current chromatography for the approved LC-MS/MS method.