Table 2.
Factors associated with neurocognitive performance in HIV-HCV coinfected patients, multivariable linear regression models, the ANRS CO13 HEPAVIH cohort and the HEPAVIH-Psy cross-sectional survey (N = 139).
| ROCF | Verbal Fluency (N = 134) | Coding (N = 135) | TMT B-A 1 (N = 132) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Copy (N = 134) | Delayed Reproduction (N = 131) 2 | |||||||||
| Coefficient (95% CI) | p-Value | Coefficient (95% CI) | p-Value | Coefficient (95% CI) | p-Value | Coefficient (95% CI) | p-Value | Coefficient (95% CI) | p-Value | |
| Coffee intake | ||||||||||
| ≤2 cups/day | 3.35 (−0.28 to 6.99) |
0.070 | 3.05 (−0.78 to 6.87) |
0.117 | 2.32 (−0.33 to 4.97) |
0.085 | 7.58 (0.18 to 14.97) |
0.045 | −0.11 (−0.28 to 0.07) |
0.226 |
| ≥3 cups/day | 4.63 (0.88 to 8.39) |
0.016 | 2.70 (−1.44 to 6.84) |
0.199 | 3.08 (0.18 to 5.97) |
0.037 | 9.24 (1.26 to 17.36) |
0.024 | −0.27 (−0.47 to −0.07) |
0.009 |
| Age | 0.10 (−0.04 to 0.25) |
0.165 | −0.09 (−0.26 to 0.09) |
0.333 | 0.03 (−0.12 to 0.16) |
0.701 | −0.82 (−1.18 to −0.46) |
0.000 | 0.00 (−0.01 to 0.01) |
0.608 |
| Educational level 3 | −1.19 (−2.79 to 0.41) |
0.145 | 2.06 (−0.08 to 4.20) |
0.059 | 0.59 (−1.25 to 2.42) |
0.527 | 1.03 (−2.93 to 5.00) |
0.607 | −0.06 (−0.17 to 0.05) |
0.302 |
| Current MDD | −1.88 (−4.61 to 0.85) |
0.176 | −2.81 (−5.23 to −0.38) |
0.024 | −0.73 (−2.74 to 1.29) |
0.477 | −6.75 (−11.50 to −2.00) |
0.006 | 0.05 ( −0.11 to 0.22) |
0.529 |
| Presence of cirrhosis | −2.28 (−4.49 to −0.07) |
0.043 | −1.12 (−3.60 to 1.38) |
0.380 | −1.07 (−3.04 to 0.89) |
0.282 | −4.38 (−9.23 to 0.47) |
0.076 | 0.07 (−0.06 to 0.19) |
0.288 |
| Ongoing HCV treatment | 0.26 (−1.67 to 2.18) |
0.792 | 0.13 (−3.15 to 3.40) |
0.939 | −2.43 (−4.72 to −0.13) |
0.039 | −9.01 (−14.14 to −3.88) |
0.001 | 0.00 (−0.14 to 0.15) |
0.988 |
| Detectable HIV viral load | 0.13 (−1.83 to 2.09) |
0.896 | −0.71 (−3.56 to 2.14) |
0.623 | −1.73 (−4.41 to 0.96) |
0.205 | −10.97 (−17.38 to −4.55) |
0.001 | 0.21 (0.05 to 0.38) |
0.013 |
| Cannabis use | −0.89 (−2.65 to 0.87) |
0.320 | −0.46 (−2.70 to 1.78) |
0.685 | −1.77 (−3.61 to 0.06) |
0.058 | −4.91 (−8.98 to −0.84) |
0.019 | 0.09 (−0.03 to 0.20) |
0.149 |
1 TMT B-A was log10-transformed so results must be interpreted as 10^Est. 2 Adjusted for quality of the copy and for reproduction time (log10 transformed). 3 Educational level above or equal to the French Baccalaureate. Abbreviations: ROCF: Rey-Osterrieth complex figure; MDD: major depressive disorder; HCV: hepatitis C virus; TMT B-A: trail making test part B minus A.