Figure 6.

CLN3-derived BMECs show an abnormal angiogenic phenotype. (a) Cell migration assay and (b) cell proliferation assay. (c–e) Angiogenic assays were performed on iPSC-derived BMECs seeded on growth-factor reduced Matrigel at a density of 10,000 cells/cm². Total tube length (c), number of nodes (d), and number of junctions (e) were quantified from images obtained (Figure S-1A,B) at different time points. Values represent means ± SEM of N = 3/group, * denotes P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.