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Effect of mutations on CDT-induced HeLa cytotoxicity. (a) Clonogenic survival of HeLa cells after 10 days of treatment with HducCDT mutants at the indicated concentrations. The table presents the mean survival at 5 ng/µL ± SD of three independent experiments; (b) representative cell cycle analysis of HeLa cells after 36 h exposure to HducCDT WT and mutants at the indicated concentrations. NT: Untreated cells.
