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. 2020 Aug 26;12(9):547. doi: 10.3390/toxins12090547

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Deficiency of IL-17A did not affect adenine-induced kidney damage. (a) Experimental course of wild-type (WT) and IL-17A knockout (IL17 KO) mice treated with or without adenine. (b) Blood urea nitrogen (BUN) and creatinine levels. (c) Histological analysis of the kidney sections using Masson’s trichrome, Sirius red and F4/80 stain. Scale bar, 200 μm. (d) mRNA expression levels of IL-17A, XDH, and fibrosis-related genes in the kidney. *** p < 0.001 compared between indicated groups (ANOVA).