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Absorption, Distribution, Metabolism, and Excretion (ADME) parameters related to the theopapuamides A-D pharmacokinetics.
| Theopapuamides | ||||
|---|---|---|---|---|
| A | B | C | D | |
| GI absorption | Low | Low | Low | Low |
| BBB permeable | No | No | No | No |
| P-gp substrate | Yes | Yes | Yes | Yes |
| CYP1A2 inhibitor | No | No | No | No |
| CYP2C19 inhibitor | No | No | No | No |
| CYP2C9 inhibitor | No | No | No | No |
| CYP2D6 inhibitor | No | No | No | No |
| CYP3A4 inhibitor | No | No | No | No |
| Log K (skin permeation) | −19.30 | −19.37 | −18.28 | −17.98 |
| (cm/s) | ||||
