Figure 1.

Iron transport inside the brain. A scheme of proposed transferrin-bound and non-transferrin bound iron transport pathways in the brain. Abbreviations: BVEC—blood vascular endothelial cell, Tf—transferrin, TfR1—transferrin receptor 1, Fe³⁺—ferric iron, Fe²⁺—ferrous iron, DCYTB—duodenal cytochrome b, DMT1—divalent metal transporter-1, FPN1—ferroportin-1, LIP—labile iron pool, CP—ceruloplasmin, HEPH—hephaestin, NTBI—non-transferrin-bound iron, FT—ferritin, H-FT—H-ferritin, TIM-1—T-cell immunoglobulin and mucin domain.