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. 2020 Sep 22;12(9):2895. doi: 10.3390/nu12092895

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Short-term evaluation of OT-58 on the background of current standard of care for HCU. Ten HO mouse cohorts (n = 3 males + 3 females each) were set on a different dietary regime evaluating normal or decreased Met content in the diet (MET4.0/2.0/1.0/0.5), Bet supplementation (2% Bet water), and dietary Cys supplementation (3xCYS). After acclimation, the efficacy of OT-58 treatment was assessed according to the study design shown in the bottom right corner. (a) Plasma Met, (b) plasma tHcy, (c) plasma tCys, (d) plasma Cth, (e) plasma Bet. Solid lines and closed symbols represent cohorts without Bet supplementation, while dashed lines and open symbols denote cohorts with Bet supplementation. Data points and error bars represent means and standard errors of means, respectively.