Figure 3.

Long-term evaluation of OT-58. Three HO mouse cohorts (n = 4 males + 4 females each) were set on diets with reduced (MET0.5), normal (MET4.0), and increased (MET8.2) Met content later combined with Bet supplementation. OT-58 efficacy was evaluated on the background of these dietary regimes and later challenged by switching cohorts between the three diets as outlined in study design shown at the top. (a) Plasma Met, (b) plasma tHcy, (c) plasma tCys, (d) plasma Cth. Data points and error bars represent means and standard errors of means, respectively.