Table 2.
Effect of Pt-PS on body weight, blood glucose, insulin, and adipokines in high-fat-diet (HFD)-fed mice.
| Control | HFD | Sb-PS | Pt-PS | |
|---|---|---|---|---|
| Body weight gain (g) | 12.21 ± 1.33 | 25.07 ± 2.67 ## | 20.52 ± 1.86 * | 16.61 ± 1.44 ** |
| Food intake (g/w) | 30.86 ± 2.75 | 25.95 ± 2.04 # | 25.67 ± 2.23 | 26.20 ± 2.49 |
| Calorie intake (kcal/w) | 126.38 ± 9.94 | 170.27 ± 11.36 # | 168.78 ± 12.47 | 171.44 ± 16.35 |
| Perirenal fat weight (g) | 0.20 ± 0.01 | 0.64 ± 0.07 ## | 0.41 ± 0.03 ** | 0.31 ± 0.02 ** |
| Epididymal fat weight (g) | 0.58 ± 0.06 | 2.28 ± 0.30 ## | 1.84 ± 0.21 * | 1.17 ± 0.16 ** |
| Abdominal subcutaneous fat weight (g) | 0.19 ± 0.01 | 0.92 ± 0.09 ## | 0.65 ± 0.07 * | 0.45 ± 0.08 ** |
| Hepatic weight (g) | 1.13 ± 0.12 | 1.95 ± 0.14 ## | 1.50 ± 0.20 * | 1.36 ± 0.15 ** |
| Fasting blood glucose (mmol/L) | 7.73 ± 0.57 | 12.01 ± 0.94 ## | 9.30 ± 0.87 * | 8.48 ± 0.90 ** |
| Serum insulin (mU/L) | 9.26 ± 0.85 | 14.04 ± 1.32## | 11.36 ± 0.89 * | 10.42 ± 1.01** |
| HOMA-IR | 3.20 ± 0.36 | 7.59 ± 0.84 ## | 4.63 ± 0.52 ** | 3.96 ± 0.27 ** |
| QUICKI | 0.54 ± 0.02 | 0.45 ± 0.02 ## | 0.49 ± 0.03 | 0.51 ± 0.01 * |
| Serum TNF-α (pg/mL) | 63.58 ± 38.92 | 126.47 ± 47.61 ## | 101.15 ± 40.03 | 86.34 ± 31.48 * |
| Serum adiponectin (ng/mL) | 173.45 ± 15.21 | 82.67 ± 6.89 ## | 144.73 ± 11.40 ** | 162.06 ± 9.74 ** |
| Serum leptin (ng/mL) | 0.18 ± 0.02 | 0.46 ± 0.04 ## | 0.39 ± 0.05 | 0.24 ± 0.03 ** |
| Serum resistin (ng/mL) | 4.27 ± 0.30 | 11.26 ± 0.87 ## | 7.85 ± 0.69 ** | 5.94 ± 0.82 ** |
Data are presented as mean ± S.D. Multiple comparisons were done using one-way ANOVA. The values of the first seven parameters were acquired from all animals (n = 14), while other parameters were determined from mice injected with normal saline (n = 7). # p < 0.05, ## p < 0.01 vs. control; * p < 0.05, ** p < 0.01 vs. HFD group. Sb-PS, PS from soybean; HOMA-IR; QUICKI, quantitative insulin sensitivity check index.