Figure 1.

JCPyV genome undergoes rearrangement in progressive multifocal leukoencephalopathy (PML). Left panel: Archetype JCPyV develops a persistent infection in the kidneys and is generally asymptomatic. PML-type JCPyV is a rearranged form with one or more deletions or duplications of genomic block sequence in the non-coding control region (NCCR) (shown above in expanded form as a deletion of blocks b and d and a duplication of blocks a, c and e) and is found in the brain, cerebrospinal fluid (CSF) and blood. Right panel: Early genes include large T and small t antigens and are transcribed first. Late genes include structural proteins and additional regulatory proteins. Early and late genes are separated by the NCCR and are transcribed in opposite directions. ORI—origin of replication; NCCR—non-coding control region; T—T antigen and splice variants. Agno: JCPyV agnoprotein. Adapted from [30] and [126].