Figure 3.

Model of JCPyV CNS entry by choroid plexus. Evidence suggests JCPyV may utilize extracellular vesicles (EVs) in entry of the CNS. A model proposed by O’Hara et al. theorizes JCPyV may pass into the stroma from the bloodstream as either free virions or enclosed in capsules. JCPyV is then able to infect choroid plexus epithelial (CPE) cells which package and release the virions in EVs into the CSF. JCPyV-containing EVs then enter the brain parenchyma and infect glial cells without necessitating the use of the LSTc cellular entry receptor. Adapted from [194].