. 2020 Aug 28;12(9):955. doi: 10.3390/v12090955

Table 1.

HuNoV fecal shedding and diarrhea after inoculation of Gn pigs with different doses of Cin-2.

Dose Group	# of Viral Genome Copies	n	Virus Shedding				Diarrhea
Dose Group	# of Viral Genome Copies	n	(%) ^a	Mean Duration Days (SEM) ^c–e	AUC ^d,f	Mean Onset Day (SEM) ^c,d	(%) ^b	Mean Duration Days (SEM) ^c–e	AUC ^d,f	Mean Onset Day (SEM) ^c,d
1	2 × 10⁶	4	4 (100%)	2.5 (0.6) ^BC	9506 ^B	2 (0.4) ^B	4 (100%)	5.0 (0.3) ^A	9.06 ^A	1.5 (0.5) ^D
2	4 × 10⁵	4	4 (100%)	1.3 (0.3) ^CD	5232 ^B	4 (1.2) ^AB	3 (75%)	1.3 (0.9) ^ABC	7.04 ^A	5.5 (1.2) ^ABC
3	2 × 10⁵	4	4 (100%)	6.3 (0.5) ^A	126774 ^A	1.3 (0.3) ^B	4 (100%)	4.0 (0.9) ^AB	9.31 ^A	2.8 (0.5) ^CD
4	8 × 10⁴	6	6 (100%)	2.8 (0.5) ^B	13495 ^B	1.5 (0.3) ^B	6 (100%)	3.8 (1) ^AB	7.46 ^A	3.2 (0.9) ^CD
5	2 × 10⁴	3	2 (67%)	1 (0.6) ^B	93 ^B	3.3 (2.3) ^AB	0 (0%)	0.0 (0) ^ABC	1.50 ^B	6.3 (1.7) ^AB
6	3.2 × 10³	3	2 (67%)	1.3 (0.9) ^BCD	2667 ^B	4 (2.1) ^AB	1 (33%)	1.0 (0) ^BC	3.17 ^AB	5 (2.1) ^BC
7	8 × 10²	4	1 (25%)	0.5 (0.5) ^D	2972 ^B	6.8 (1.3) ^A	0 (0%)	0.0 (0) ^C	2.75 ^AB	8 (0) ^A

a. Gn pigs were orally inoculated with HuNoV GII.4/2003 variant (Cin-2) at 33–34 days of age. Rectal swabs were collected daily after inoculation from PID 1-7 to determine virus shedding by RT-qPCR. b. Fecal consistency was assessed from PID 1-7 as 0, solid; 1, pasty; 2, semiliquid; 3, liquid. Pigs with daily fecal consistency scores of 2 or greater were considered to be diarrheic. c. SEM, standard error of the mean. d. Numbers in the same column followed by different capital letters (A, B, C, D) differ significantly (Tukey-Kramer HSD, p < 0.05); while shared letters indicate no significant difference. e. As pigs were sacrificed on PID 7, some data are right censored (>7). A value of 7 was substituted in mean calculations. f. AUC, area under the curve.