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. 2020 Aug 25;12(9):932. doi: 10.3390/v12090932

Figure 3.

Figure 3

Necroptotic cell death of RSV-infected macrophages via RIPK3-MLKL pathway. (a) Human THP-1 macrophages were infected with RSV (MOI = 1) in the presence of either vehicle (DMSO) or RIPK3 inhibitor GSK’872 (20 µM and 40 µM). LDH release was measured (at OD of 450 nm) at 16 h post-infection (n = 16 technical replicates from two independent experiments). * p ≤ 0.05 using a Student’s t-test. (b) Human THP-1 macrophages were infected with RSV (MOI = 1) in the presence of either vehicle (DMSO) or MLKL inhibitor Necrosulfonamide (20 µM). LDH release was measured (at OD of 450 nm) at 16h post-infection (n = 14 technical replicates from two independent experiments). * p ≤ 0.05 using a Student’s t-test.