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. 2020 Sep 3;12(9):977. doi: 10.3390/v12090977

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic of Janus kinase (JAK) protein domain architecture and the mechanism of JAK activation. (A) JAK domain architecture and the biological defects and phenotypes observed in JAK family member knockout (KO) mice. gp130, glycoprotein 130; IL-6, interleukin 6; IL-6R, IL-6 receptor; FERM, 4.1 protein, Ezrin, Radixin, Moesin; SH2, Src Homology 2; JH2, JAK homology domain 2; JH1, JAK homology domain 1. (B) The mechanism of JAK activation. Details are discussed in the text. IL, interleukin; IFN, interferon; EPO, erythropoietin; GM-CSF, granulocyte macrophage colony stimulating factor; SCID, Severe Combined Immunodeficiency [98,99,100,101]. Figure created using BioRENDER.com.