Skip to main content
. 2020 Sep 3;12(9):977. doi: 10.3390/v12090977

Figure 4.

Figure 4

Overview of the JAK/STAT signalling pathway. Upon extracellular ligand binding to their cognate receptors, auto- and/or trans-phosphorylation of JAKs and receptor tyrosine residues occurs, acting as docking sites for STAT proteins. JAK activation leads to the phosphorylation, dimerisation and activation of STAT proteins. Dimerised STATs then translocate into the nucleus and regulate gene transcription by binding to ISRE or GAS elements. Detailed descriptions are outlined in the text. IL, interleukin; IFN, interferon; IFNAR, IFN-α receptor; IFNGR, INF-γ receptor; IFNLR, IFN-λ receptor; EGF, epidermal growth factor; EGFR, EGF receptor; GM-CSF, granulocyte macrophage colony stimulating factor; S1P, sphingosine-1-phosphate; S1PR1, sphingosine-1-phosphate receptor 1; SFKs, Src family kinases; IRF9, interferon regulatory factor 9; ISGF3, interferon stimulated gene factor 3; ISRE, interferon stimulated response element; GAS, gamma interferon activation site. Figure created using BioRENDER.com.