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. 2020 Sep 5;12(9):989. doi: 10.3390/v12090989

Figure 5.

Figure 5

Characterization of GII.2 Chapel Hill Alanine mutant VLPs. (A) A panel of 5 alanine mutant VLPs were constructed comprising variable residues between GII.2 1976 SMV and GII.2 Chapel Hill within the P2 domain. Sequence alignments of variable residues within the 5 alanine mutants are compared against the Chapel Hill backbone. Color coordinated highlighted regions are highlighted on the GII.2 P domain dimer in (B). VLP binding to A and B saliva (C,D) were analyzed via one-site specific binding curve, fitted with error bars representing standard error of the mean.