Table 1.
Chemicals and their anti-inflammatory effect in mastitis by suppression NF-κB signaling.
| Authors | Agent | Function | Targets |
|---|---|---|---|
| Sun et al. [113] | H2S | Block TLR4, ROS, NF-κB | |
| Garcia et al. [125] | Citrus oils | Antibacterial | Down-regulate TLR2, NFKBIA, IL8, TNF-α |
| Wang et al. [78] | Morin | Anti-inflammatory | Inhibit IL-6, TNF-α, IL-1β, suppress NF-κB phosphorylation |
| Li et al. [126] | 8-Methoxypsoralen | Anti-inflammatory | Inhibit IL-6, TNF-α, IL-8, IL-1β, suppress NF-κB phosphorylation |
| Chen et al. [36] | Nuciferine | Anti-inflammatory | Inhibit TLR4, TNF-α, IL-1β, suppress NF-κB phosphorylation |
| Yang et al. [127] | Oxymatrine | Anti-inflammatory | Suppress NF-κB phosphorylation |
| Ershun et al. [128] | Cepharanthine | Anti-inflammatory | Inhibit IL6, TNF-α, IL-1β, suppress NF-κB phosphorylation |
| Su et al. [129] | Rutin | Decrease level of IL-1β, IL-6, and TNF-α, suppress NF-κB phosphorylation | |
| Liu et al. [112] | Sodium houttuyfonate | Antinflammatory | Inhibit NF-κB phosphorylation |
| Li et al. [130] | Emodin ameliorates | Anti-inflammatory, antibacterial | Decrease level of IL-1β, IL-6, and TNF-α, suppress NF-κB phosphorylation |
| Hu et al. [42] | Cynatratoside-C from Cynanchum atratum | Anti-inflammatory | Suppress TLR4, inhibit NF-κB phosphorylation |
| He et al. [131] | Docosahexaenoic acid | Anti-inflammatory | Decrease level of IL-1β, IL-6, and TNF-α, suppress NF-κB phosphorylation |
| He et al. [132] | Baicalein | Anti-inflammatory | Suppress TLR4, inhibit NF-κB phosphorylation |